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基因,重组蛋白,抗体

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重组人Cadherin-8/CDH8(钙黏蛋白8)
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产品: 浏览次数:725重组人Cadherin-8/CDH8(钙黏蛋白8) 
型号: 10144-H08H
规格: 20µg
单价: 面议
最小起订量:
供货总量:
发货期限: 自买家付款之日起 3 天内发货
有效期至: 长期有效
最后更新: 2010-06-09 16:38
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详细信息

Macrophage colony-stimulating factor 1 receptor Protein Datasheet

 

CSF1R/MCSF Receptor Protein Price Information

  • ≥1mg Bulk:  Inquiring Price

CSF1R/MCSF Receptor Protein Product Information

CSF1R/MCSF Receptor Synonym : M-CSF R, CSF1R, FMS, CSFR, FIM2, C-FMS, CD115
Protein Construction: A DNA sequence encoding the extracellular domain (Met 1- Glu512) of human M-CSFR (NP_005202.2 ) precursor was expressed with the fused C-terminal polyhistide-tagged.
Source: Human
Expression Host: Human Cells

CSF1R/MCSF Receptor Protein QC Testing

Purity: > 98%, as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE
Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ile 20
Molecular Mass: The recombinant human M-CSFR contains 504 amino acids after the removal of signal peptide with a calculated molecular mass of 56 kDa. As a result of glycosylation, it migrates as an approximately 85-95 kDa protein in SDS-PAGE under reducing conditions.
Formulation: Supplied as a 0.2m filtered solution of PBS, pH7.4

CSF1R/MCSF Receptor Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Reconstitution: Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents.

CSF1R/MCSF Receptor Protein Description

M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1, a cytokine involved in the proliferation, differentiation, and activation of macrophages. As a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs), M-CSF receptor is expressed mainly on cells of monocyte/macrophage lineage, and consists of an extracellular ligand-binding domain and a cytoplasmic protein tyrosine kinase (PTK) domain joined through a single transmembrane helix. Ligand binding induces the M-CSF receptor homodimerization, and leads to transphosphorylation of specific tyrosine and the subsequent signal transduction. This activated receptor exerts actions on multiple intracellular effectors which determine the magnitude and specificity of the biological responses, and thus mediates most if not all of the biological effects of the CSF1 cytokine, including cell growth, survival, differentiation and chemotaxis. Mutations of this gene have been associated with a predisposition to myeloid malignancy.

CSF1R/MCSF Receptor Protein Related Products &Topics

  • CSF1R/MCSF Receptor Protein Related Areas:
    • Cancer>>Growth Factor & Receptor>>CSF & Receptor>>CSF1R/MCSF Receptor/CD115
    • Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>CSF1R/MCSF Receptor/CD115
    • Immunology>>Cytokine>>CSF & Receptor>>CSF1R/MCSF Receptor/CD115
    • Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>> CSF1R/MCSF Receptor/CD115
    • Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>> CSF1R/MCSF Receptor/CD115
  • Proteins:
  • Antibodies:

References

  1. Sherr, C.J, 1988, Biochim.Biophys. Acta. 948 : 225-243.
  2. Rohrschneider, L.R. et al., 1997, Mol. Reprod. Dev. 46: 96-103.
  3. Hamilton J.A. et al., 1997, J. Luekoc. Biol. 62: 145-155.
  4. Roussel, M.F. et al., 1991, Nature. 353 : 361-363.
  5. Yeung, Y. et al., 1998, J. Biol.Chem. 273 :
  6. Pixley, F.J. et al., 2004, Trends.Cell.Biol. 14: 628-638.
  7. Rovida, E. et al., 2001, J. Immunol. 166:1583-1589.
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