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基因,重组蛋白,抗体

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钙黏蛋白4
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产品: 浏览次数:626钙黏蛋白4 
型号: 10230-H08H
规格: 100µg
单价: 面议
最小起订量:
供货总量:
发货期限: 自买家付款之日起 3 天内发货
有效期至: 长期有效
最后更新: 2010-06-09 16:44
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详细信息

Activin receptor, type-2B Protein

 

ACVR2B Protein Price Information

≥1mg Bulk:  Inquiring Price

ACVR2B Protein Product Information

ACVR2B Synonym : ACVR2B, ACTRIIB, ActR-IIB, MGC116908
Protein Construction: A DNA sequence encoding the extracellular domain of human ACVR2B (NP_001097.2 ) (Met 1- Thr 134) was fused with a polyhistidine tag at the C-terminus.
Source: Human
Expression Host: Human Cells

ACVR2B Protein QC Testing

Purity: ﹥97 % as determined by SDS-PAGE. SDS-PAGE:
SDS-PAGE
Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ser 19
Molecular Mass: The recombinant human ACVR2B comprises 127 amino acids and predicts a molecular mass of 15 KDa. As a result of glycosylation, rh ACVR2B migrates as an approximately 33-38 KDa protein in SDS-PAGE under reducing conditions.
Formulation: Supplied as a 0.2μm filtered solution of PBS, pH7.4

ACVR2B Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted and be used as soon as possible.; Avoid repeated freeze-thaw cycles
Reconstitution: Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents.

ACVR2B Protein Description

Activin isoforms are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-β) superfamily of structurally related signaling proteins. Activins exert their biological actions by binding to heteromeric receptor complexes consisting of at least two type I (I and IB) and two type II (II and IIB) receptor. These Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine kinase activity. Type I receptors are essential for signal transduction and type II receptors are required for ligand binding and the expression of type I receptors. On ligand binding, Type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently the activation of downstream molecules including the endogenous Smads is initiated. This protein, activin A type IIB receptor, displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

ACVR2B Protein Related Products &Topics

  • ACVR2B Protein Related Areas:
    • Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ACVR2B
    • Immunology>>Cytokine>>TGF-beta Superfamily>>Activin/Inhibitin>>ACVR2B
    • Immunology>>Cytokine>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ACVR2B
  • Proteins:
  • Antibodies:

References

  1. Attisano, L. et al., 1996, Mol. Cell. Biol. 16: 1066-1073.
  2. Hilden, K. et al., 1994, Blood, 83: 2163-2170.
  3. Persson, U. et al., 1997, J.Biol.Chem. 272: 21187-21194.
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