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基因,重组蛋白,抗体

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重组人BMPR-II/BMPR2(骨形成蛋白II型受体)
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产品: 浏览次数:784重组人BMPR-II/BMPR2(骨形成蛋白II型受体) 
型号: 10551-H08H
规格: 200µg
单价: 面议
最小起订量:
供货总量:
发货期限: 自买家付款之日起 3 天内发货
有效期至: 长期有效
最后更新: 2010-06-09 16:45
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详细信息

Aminoacylase 1 Protein Datasheet

 

aminoacylase Protein Price Information

  • 200ug:  Inquiring Price;
  • ≥1mg Bulk:  Inquiring Price

aminoacylase Protein Product Information

aminoacylase Synonym : ACY1D, ACYLASE,ACY1
Protein Construction: A DNA sequence encoding the full length of human ACY1 (NP_000657.1) (Met 1-Ser 408) was expressed with a polyhistidine tag at the C-terminus.
Source: Human
Expression Host: Baculovirus

aminoacylase Protein QC Testing

Purity: > 95%, as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE
Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Met
Molecular Mass: The recombinant human ACY1 consists of 419 amino acids and predicts a molecular mass of 47.3 kDa. It migrates as an approximately 44 kDa protein in SDS-PAGE under reducing conditions.
Formulation: Supplied as a 0.2μm filtered solution of 50mM Tris, 100mM NaCl, pH 8.0, 10% glycerol

aminoacylase Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Reconstitution: Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents.

aminoacylase Protein Description

Aminoacylase 1, also known as ACY1, is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and plays a general role in the cytosolic breakdown of acetylated amino acids generated during protein degradation. As the first member of the zinc-binding enzyme family, ACY1 is expressed in a wide range of tissue with the highest level in the kidney tubular epithelium, and functions in the catabolism and salvage of acylated amino acids. ACY1 is capable of interacting with sphingosine kinase type 1 (SPHK1), which is involved in promoting cell growth and inhibiting apoptosis of tumor cells. ACY1 has been reported to exhibit reduced or absent expression in SCLC cell lines tumors and RCCs. This enzyme is evolutionarily conserved in fish, frog, mouse, and human, and the amino acid sequence of human ACY1 is 93% identical to that of mouse. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D), an inborn metabolic disorder exhibiting markedly increased urinary excretion of several N-acetylated amino acids.

aminoacylase Protein Related Products &Topics

  • aminoacylase Protein Related Areas:
  • Proteins:
  • Antibodies:

References

  1. Miller, Y.E. et al.,1989, J. Clin. Invest. 83: 2120-2124.
  2. Cook, R.M. et al.,1993, J. Biol. Chem. 268: 17010-17017.
  3. Maceyka, M. et al., 2004, FEBS Lett. 568: 30-34.
  4. Lindner, H .A. et al.,2008, Biochimie. 90:773-580.
  5. Van Coster R.N. et al.,2005, Biochem. Biophys. Res. Commun. 338:1322-1326.
 
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