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基因,重组蛋白,抗体

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您当前的位置:首页 » 供应产品 » CDH2/CD325(钙黏蛋白2
CDH2/CD325(钙黏蛋白2
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产品: 浏览次数:2717CDH2/CD325(钙黏蛋白2 
型号: 11039-H08H
规格: 100µg
单价: 面议
最小起订量:
供货总量:
发货期限: 自买家付款之日起 3 天内发货
有效期至: 长期有效
最后更新: 2010-06-09 16:54
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详细信息

Inter-Cellular Adhesion Molecule 1 ( ICAM1 / CD54 ) Protein Datasheet

 

ICAM1 / CD54 Protein Price Information

  • 500ug:  Inquiring Price;
  • ≥1mg Bulk:  Inquiring Price

ICAM1 / CD54 Protein Product Information

Synonym :

BB2,  CD54,  P3.58

Protein Construction:

A DNA sequence encoding the human ICAM1 (NP_000192.2) extracellular domain (Met 1- Glu 480) was fused with the a polyhistidine tag at the C-terminus.

Source: Human
Expression Host: Human Cells

ICAM1 / CD54 Protein QC Testing

Purity:

> 98 % as determined by SDS-PAGE.

SDS-PAGE:
SDS-PAGE
Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Gln 28
Molecular Mass:

The recombinant human ICAM1 consists of 464 amino acids and has a predicted molecular mass of 51 kDa. As a result of glycosylation, the apparent molecular mass of rhICAM1 is approxiamtely 65-70 kDa in SDS-PAGE under reducing conditions.

Formulation:

Supplied as a 0.2μm filtered solution of PBS,  pH7.4

ICAM1 / CD54 Protein Usage Guide

Storage:

Store it under sterile conditions at -70℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.

Reconstitution: Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents.

ICAM1 / CD54 Protein Description

ICAM1 (Inter-Cellular Adhesion Molecule 1), also known as CD54, is a type of intercellular adhesion molecule constitutely present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. ICAM1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease.

ICAM1 / CD54 Protein Related Products & Topics

  • ICAM1 / CD54 Protein Related Areas:
    • Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Migration/Adhesion>>ICAM-1/CD54
    • Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>ICAM-1/CD54
    • Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>ICAM-1/CD54
    • Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Adhesion>> ICAM-1/CD54
    • Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells / T Cell Migration/Adhesion>>ICAM-1/CD54
  • Proteins:
  • Antibodies:

References

  1. Rothlein, R. et al.,1986,  Journal of Immunology. 137 (4): 1270-1274.
  2. Yang, L. et al., 2005,  Blood 106 (2): 584-592.
  3. Frijns, CJ. et al., 2002,  Stroke 33 (8): 2115-2122.
  4. Bella, J. et al., 1998,  Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4140-4145.
 
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